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Masahiro Ono, MD

Masahiro Ono, MD

Thoracic and Cardiac Surgery
For Heart Transplant and Mechanical Circulatory Support Surgeon Masahiro Ono, MD, PhD a great day is one where very complicated and challenging surgeries go well: “The OR team and I start to prepare the day before, and when the cases go well, I feel like my effort and everyone’s efforts are like a chemical reaction in the OR. And, then, when I bring the patient back for a follow-up, everyone is happy!” says Dr. Ono.

Dr. Ono was inspired to pursue a career as a surgeon early on. His father, a maxillofacial surgeon in Japan, was his primary influence. Later, after medical school and a general surgery residency at Showa University School of Medicine in Tokyo, it became clear that cardiac surgery would be his chosen subspecialty where the most acute cases offered both the greatest challenge and the greatest reward. Dr. Ono completed his cardiothoracic surgery fellowship and a PhD at Showa University. He would soon discover, however, that some patients with advanced heart failure were too sick for surgery and he decided to relocate to the United States to train in cardiac transplant and mechanical circulatory support.

Once in the US and on the advice of his mentor who advised Dr. Ono about the high value placed on research experience, Dr. Ono completed a postdoctoral research fellowship at Johns Hopkins Hospital in Baltimore, Maryland. He then secured a cardiovascular surgery fellowship at Texas Heart Institute at Baylor St. Luke’s Medical Center in Houston, Texas followed by a cardiothoracic transplant and mechanical circulatory support surgery fellowship there.

Dr. Ono joined Methodist Physician Practices in mid-2018 from Texas Heart Institute where he served as Assistant Professor in the Division of Cardiothoracic Transplant & Circulatory Support in the Michel E. DeBakey Department of Surgery at Baylor College of Medicine. Dr. Ono is the recipient of numerous research and teaching awards, including most recently the Chief Award to an Outstanding Faculty Member Selected by the Graduating Chief Residents in Cardiothoracic Surgery at Michel E. DeBakey Department of Surgery, Baylor College of Medicine. He is a member of several professional organizations, including the Japanese Surgical Society, Japanese Association for Thoracic Surgery, Japanese Society for Cardiovascular Surgery and the International Society for Heart & Lung Transplantation.
Care Philosophy

Heart Transplant and Mechanical Circulatory Support Surgeon Masahiro Ono, MD, PhD is driven by the overarching goal of putting the patient at the center of every decision he makes. Further, he thinks of every patient as a member of his family and is guided by what he would do if the patient he is caring for were his wife or his grandfather, for example. Dr. Ono makes every effort to spend as much time as possible with his patients and their families so they can connect with him and feel comfortable asking all their questions.

Advanced Heart Failure

Bridge to Transplant

Cardiac device implantation

Cardiac Transplantation

Cardio-Thoracic Surgery

Cardiothoracic Transplant

Cardiovascular Surgery


Destination Therapy Left Ventricular Assist Devices (DT LVAD)

Heart Transplant Surgery

HeartAssist 5

HeartMate II

HeartMate XVE


Mechanical Circulatory Support (MCS)

Post-Cardiotomy Shock


Thoratec pVAD and Thoratec iVAD Bridge to Recovery

Ventricular Assist Device Implantation and Management